Search results for "active metabolites"

showing 5 items of 5 documents

Variations of essential oil constituents in oregano (Origanum vulgare subsp. viridulum (= o. heracleoticum) over cultivation cycles

2020

Oregano is&mdash

0106 biological sciencesHarvest timearomatic plants cultivationPlant Science01 natural sciencesessential oillaw.inventionactive metabolitechemistry.chemical_compoundlawthymolThymolSicilyEcology Evolution Behavior and SystematicsEssential oilEcologybiology010405 organic chemistryBotanyactive metabolitesOriganumbiology.organism_classification0104 chemical sciencesSettore AGR/02 - Agronomia E Coltivazioni ErbaceeHorticulturechemistryQK1-989Composition (visual arts)oreganoharvest time010606 plant biology & botany
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Substantial Fat Loss in Physique Competitors Is Characterized by Increased Levels of Bile Acids, Very-Long Chain Fatty Acids, and Oxylipins.

2022

Funder: Finnish Foundation for Cardiovascular Research

LC-MS metabolomeexercisekuntoliikuntalaihdutusvisceral fat massliikuntaweight lossbioactive metabolitesaineenvaihduntafyysinen aktiivisuusArticlepainonhallinta
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Antifungal Activity of Bioactive Metabolites Produced by Trichoderma asperellum and Trichoderma atroviride in Liquid Medium

2020

Trichoderma spp. are known as biocontrol agents of fungal plant pathogens and have been recognized as a potential source of bioactive metabolites. The production of antimicrobial substances from strains T. atroviride (TS) and T. asperellum (IMI 393899) was investigated. The bioactivity of 10- and 30-day culture filtrate extracted with ethyl acetate was assessed against a set of pathogenic fungi and oomycetes. The 30-day extracts of both strains had significant cytotoxic effects against the tested pathogens, with values of minimum fungicidal concentration (MFC) ranging between 0.19 and 6.25 mg/mL. Dual culture assay (direct contact and nondirect contact) and the percentage inhibition of radi…

Microbiology (medical)Ethyl acetateBiological pest controlbiological controlPlant ScienceLiquid mediumplant pathogensTrichoderma atroviride03 medical and health scienceschemistry.chemical_compoundFood science<i>Trichoderma asperellum</i>lcsh:QH301-705.5Ecology Evolution Behavior and Systematics030304 developmental biology0303 health sciencesbiology030306 microbiologyChemistryBiological activity<i>Trichoderma atroviride</i>biology.organism_classificationAntimicrobialTrichoderma asperellumlcsh:Biology (General)Trichodermabioactive metabolitesJournal of Fungi
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Inhibition of Mycotoxigenic Fungi in Different Vegetable Matrices by Extracts of Trichoderma Species

2021

Post-harvest fungal diseases of plant products are a serious concern leading to economic losses and health risks. Moreover, the use of synthetic chemical fungicides to prevent these diseases is limited due to toxic residues. This study aimed at determining the effective dose of extracts of Trichoderma&nbsp

Microbiology (medical)Ochratoxin AAflatoxinTrichoderma asperellumQH301-705.5Biological pest controlbiological controlPlant ScienceBiologyArticlechemistry.chemical_compoundmycotoxinsFood scienceTrichoderma atrovirideBiology (General)MycotoxinEcology Evolution Behavior and Systematicsfood and beveragesContaminationTrichoderma asperellumEffective dose (pharmacology)<i>Trichoderma</i> <i>atroviride</i>FungicideTrichoderma atroviridechemistry<i>Trichoderma</i> <i>asperellum</i>bioactive metabolitesTrichoderma speciesJournal of Fungi
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Current Evidence, Challenges, and Opportunities of Physiologically Based Pharmacokinetic Models of Atorvastatin for Decision Making

2021

Atorvastatin (ATS) is the gold-standard treatment worldwide for the management of hypercholesterolemia and prevention of cardiovascular diseases associated with dyslipidemia. Physiologically based pharmacokinetic (PBPK) models have been positioned as a valuable tool for the characterization of complex pharmacokinetic (PK) processes and its extrapolation in special sub-groups of the population, leading to regulatory recognition. Several PBPK models of ATS have been published in the recent years, addressing different aspects of the PK properties of ATS. Therefore, the aims of this review are (i) to summarize the physicochemical and pharmacokinetic characteristics involved in the time-course o…

Physiologically based pharmacokinetic modellingModel predictionAtorvastatinPopulationPharmaceutical ScienceReviewTarget populationComputational biologyP-glycoprotein030226 pharmacology & pharmacy03 medical and health sciencesPharmacy and materia medica0302 clinical medicinePharmacokineticsmedicineopen acid formeducationeducation.field_of_studybusiness.industrysolubilityatorvastatinactive metabolitesRS1-441lactonizationDose optimizationMetabolic enzymes030220 oncology & carcinogenesisbusinessmedicine.drugPharmaceutics
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